On this date in 1843, Robert Koch, the founder of modern microbiology was born. And on December 10, 1905, one day before his 62nd birthday, he was awarded the Nobel Prize in Physiology or Medicine for his work on tuberculosis.
But what many microbiologists are more familiar with are the Koch’s postulates, four criteria needed to establish a causal relationship between microbe and disease. These are:
- The microorganism must be found in individuals suffering from the disease, but in not healthy individuals,
- The microorganism must be isolated from a diseased individual and grown in pure culture,
- The cultured microbe should cause disease when introduced into a healthy individual, and
- The microbe must be isolated from the inoculated individual and identified as the same microbe from the original source.
Now, more than a century after Koch’s time, how do these postulates hold up? (more…)