Skip to content
The Microbial Menagerie
Menu
  • Home
  • About
    • Blog News and Updates
    • About Jennifer
    • My Other Writing
    • Write a Guest Post
    • Contact Me
    • Privacy Policy and Disclosures
  • Microbes and Microbiologists
    • Meet a Microbiologist
    • Meet a Microbe
    • Microbiology Poems
  • Microbiome
    • Human Microbiome
    • Built Environments
  • Fermented Foods
    • Bread
    • Cheese
    • Kefir
    • All Fermented Foods
  • Diseases and Immunity
    • COVID-19
    • Antimicrobial Resistance
    • Vaccines
    • Infectious Diseases
  • Other
    • Agar Plates
    • Applied Microbiology
    • Fungi
    • Microbes in the Environment
    • Microbial Physiology
    • Microbiology Research Updates
    • Science Communication
    • Microbiology History
    • Microbiology Books
Menu

Giant Genes for Tiny Organisms

Posted on February 4, 2018July 7, 2022 by Jennifer Tsang

How big can a gene be? Ten years ago in the early days of genome sequencing, researchers scoured the genomes of 580 bacterial and archaeal species for large genes. They found that 0.2% of all genes identified are longer than 5,000 bases and 80 of them are “giant genes,” those larger than 15,000 bases. To put this in perspective, the average prokaryotic gene length is between 900 and 1,200 bases.

The two longest genes were found in the green sulfur bacterium Chlorobium chlorochromatii CaD3. The genes encode proteins 36,806 and 20,647 amino acids long and their corresponding genes would be 110,418 and 61,941 bases long, respectively. At the time of this research, these giant genes are only surpassed in length by the human titin coding sequence which is 38,138 amino acids long. Now, scientists have identified a slew of genes that exceed one million bases long.

Structure of a multienzyme complex. Source.

While organisms of the bacterial world tend to favor streamlined, highly efficient genomes, these giants have slipped under the radar. The type of proteins they encode could explain why. Over 90% of the giant genes encode surface proteins, such as a transporter or adhesion, or multienzyme complexes that work sequentially to transform a substrate to a desired product, usually an antifungal or antibacterial compound. These microbial weapons could give advantages to organisms that carry these giant genes when competing with other microbes for nutrients or territory. Multienzyme complexes are typically encoded by genes that sit side by side in the genome, making it easy for the genes to be turned off and on at the same time. Perhaps it was just convenient that these individual genes fused into one giant gene.

But creating such an enormous protein is quite a burden, requiring an immense investment of time, energy, and material. In optimal conditions, a cell can piece together 40 amino acids in a second. A “normal” protein could be made in a few seconds. The largest Chlorobium chlorochromatii protein identified in the study requires at least 15 minutes to make. This may still seem quick to us humans, but a bacterial life cycle lasts a matter of 20 minutes to a few weeks. If a bacterium is growing quickly, why bother making proteins from giant genes? Giant genes may only useful during periods of slow growth or in slow growing organisms.

Sure enough, most of these genes were found in environmental bacteria – those that tend to replicate slower and live in cycles of feast and famine. The 80 giant genes came from 47 species including six human pathogens, one fish pathogen, one insect pathogen, and one plant pathogen. When the study took place, most of the sequenced bacteria were human pathogens. The finding that giant genes occur preferentially in non-pathogenic environmental bacteria even when genome data is biased towards pathogens further supports the claim that giant genes are rare in pathogens and more common in environmental bacteria.

Microbial life at the extremes does always mean living in hydrothermal vents or clinging on ice floes in the Arctic. Unusual aspects of life may be stealthy, hidden within the most “ordinary” of organisms.

Loading

Share this:

  • Click to share on Twitter (Opens in new window)
  • Click to share on Facebook (Opens in new window)
  • Click to share on LinkedIn (Opens in new window)
  • Click to share on Pinterest (Opens in new window)
  • Click to share on Reddit (Opens in new window)
  • Click to email a link to a friend (Opens in new window)
  • Click to print (Opens in new window)

Related

Leave a ReplyCancel reply

This site uses Akismet to reduce spam. Learn how your comment data is processed.

Support the blog!

If you've enjoyed reading the blog, please support me on Ko-fi

Stay in Touch

Enter your email address to subscribe to this blog and receive notifications of new posts by email.

Join us on social

  • Facebook
  • Twitter
  • LinkedIn

Categories

Agar Plates Animal Microbiome Antimicrobial Resistance Applied Microbiology Blog News and Updates Built Environments COVID-19 Fermented Foods Fungi Human Microbiome Infectious Diseases Meet a Microbe Meet a Microbiologist Microbes in the Environment Microbial Physiology Microbiology Books Microbiology History Microbiology Poems Microbiology Research Updates Science Communication Vaccines

Top Posts

  • A Microbiologist’s Guide to Yogurt + Instant Pot Yogurt Recipe
  • Knitting and Crocheting Microbes
  • Blood and Bacteria: Blood Agar Reveals How Microbes “Consume” Blood
  • Meet Microbiologist Ruth Ella Moore, the First Black Woman to Earn a PhD in the Natural Sciences
  • A Bacterium You Can See With the Naked Eye

Recent Posts

  • Why do we get more colds and respiratory illnesses in the wintertime?
  • Boo! How Bacterial Ghosts Can Help Treat Disease
  • When should I get my flu shot? Here’s what science says.
  • Meet a Microbe: Anaplasma phagocytophilum
  • The Snotty Science Behind Daycare Respiratory Illness Transmission

Archives

Subscribe to Blog via Email

Enter your email address to subscribe to this blog and receive notifications of new posts by email.

© 2025 The Microbial Menagerie | Powered by Minimalist Blog WordPress Theme
 

Loading Comments...